Urinary tract infections due to Enterobacterales and their antibiotic resistance profile in rural hospital in Burkina faso
DOI:
https://doi.org/10.64707/revstss.v49i1.2042Keywords:
Infection du tractus urinaire, Milieu rural, Entérobactéries,, Hémoculture, septicémie, résistance aux antibiotiques, Staphylococcus aureus, Escherichia coli, Burkina Faso, BLSEAbstract
Antimicrobial resistance is nowadays a major public health threat. Surveillance of antimicrobial resistance is one of the key elements of Burkina Faso’s national action plan for combating this threat. We analyzed urine samples in this retrospective study to assess the carriage of Enterobacteriales and their antibiotic susceptibility.
A total of 566 urine samples were collected from January 01, 2020, to June 30, 2022, in the Nanoro health district to diagnose any urinary tract infection (UTI). Antibiotic susceptibility test was performed according to Kirby Kirby-Bauer method. The principle of action synergy was used to determine the extended-spectrum beta-lactamase (ESBL).
In total, 207 samples had confirmed UTI with two co-infections representing 209 isolated bacterial strains. The study revealed that Enterobacteriaceae were the main causes of UTIs, with a prevalence of 90.90%. Out of them, ESBL prevalence was 62,63% dominated by the genus Escherichia (70,58%), Klebsiella (12,60%), and Enterobacter (10,92%). The results of this retrospective study confirm the need for regular monitoring for better patient care management, which would contribute to alert decision-makers on the urgency of regulating any action or behavior that could contribute to the spread of antimicrobial resistance.
Key words: Urinary tract, Rural environment, Enterobacteriales, antibiotic resistance, ESBL
References
Sulis G, Sayood S, Gandra S. Antimicrobial resistance in low-and middle-income countries: current status and future directions. Expert review of anti-infective therapy. 2022;20(2):147–60.
Amabile-Cuevas C. Antibiotic resistance in Mexico: a brief overview of the current status and its causes. The Journal of Infection in Developing Countries. 2010;4(03):126–31.
Otaigbe, II, Elikwu CJ. Drivers of inappropriate antibiotic use in low- and middle-income countries. JAC Antimicrob Resist. 2023;5(3):dlad062.
Hu H-W, Wang J-T, Li J, Shi X-Z, Ma Y-B, Chen D, et al. Long-term nickel contamination increases the occurrence of antibiotic resistance genes in agricultural soils. Environmental science & technology. 2017;51(2):790–800.
Udikovic-Kolic N, Wichmann F, Broderick NA, Handelsman J. Bloom of resident antibiotic-resistant bacteria in soil following manure fertilization. Proceedings of the National Academy of Sciences. 2014;111(42):15202–7.
Wellington EM, Boxall AB, Cross P, Feil EJ, Gaze WH, Hawkey PM, et al. The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria. The Lancet infectious diseases. 2013;13(2):155–65.
Smith RA, M’ikanatha NM, Read AF. Antibiotic resistance: a primer and call to action. Health communication. 2015;30(3):309–14.
Laxminarayan R, Duse A, Wattal C, Zaidi AK, Wertheim HF, Sumpradit N, et al. Antibiotic resistance—the need for global solutions. The Lancet infectious diseases. 2013;13(12):1057–98.
Frieri M, Kumar K, Boutin A. Antibiotic resistance. Journal of infection and public health. 2017;10(4):369–78.
Faso MdlSdB. Plan d’Action National Multisectoriel de Lutte Contre la Résistance aux Antimicrobiens 2017-2020 2017.
McLellan LK, Hunstad DA. Urinary tract infection: pathogenesis and outlook. Trends in molecular medicine2016. p. 946–57.
Kaboré F, Kambou T, Zango B, Ouattara A, Simporé M, Lougué-Sorgho C, et al. Epidemiology of a cohort of 450 urolithiasis at the Yalgado Ouédraogo university hospital of Ouagadougou (Burkina Faso). Progres en Urologie: Journal de L'association Francaise D'urologie et de la Societe Francaise D'urologie. 2013;23(12):971–6.
Medina-Polo J, Naber KG, Johansen TEB. Healthcare-associated urinary tract infections in urology. GMS infectious diseases. 2021;9.
Tansarli GS, Athanasiou S, Falagas ME. Evaluation of antimicrobial susceptibility of Enterobacteriaceae causing urinary tract infections in Africa. Antimicrobial agents and chemotherapy. 2013;57(8):3628–39.
Sanou I, Kabore A, Tapsoba E, Bicaba I, Ba A, Zango B. Nosocomial Urinary Infections at the Urogoly Unit of the National University Hospital (Yalgado Ouedraogo), Ouagadougou: Feb.-Sept. 2012. African Journal of Clinical and Experimental Microbiology. 2015;16(1):1–6.
Ouedraogo S, Kpoda DS, Ouattara LP, Zongo C, Hien YE, Karfo P, et al. Identification of Bacteria Strains Isolated in Urinary Tract Infections and Their Antibiotic Susceptibility at the National Public Health Laboratory, Ouagadougou. Open Journal of Medical Microbiology. 2022;12(3):83–95.
Kpoda D, Guessennd N, Somda N, Ajayi A, Bonkoungou J, Konan F, et al. Antimicrobial susceptibility of extended-spectrum beta-lactamase producing Enterobacteriaceae causing urinary tract infections in Ouagadougou, Burkina Faso. African Journal of Clinical and Experimental Microbiology. 2017;18(3):139–44.
Magiorakos A-P, Srinivasan A, Carey RB, Carmeli Y, Falagas M, Giske C, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clinical microbiology and infection. 2012;18(3):268–81.
Tan CW, Chlebicki MP. Urinary tract infections in adults. Singapore medical journal. 2016;57(9):485.
Medina M, Castillo-Pino E. An introduction to the epidemiology and burden of urinary tract infections. Therapeutic advances in urology. 2019;11:1756287219832172.
Karou SD, Ilboudo IP, Nadembega W, Ameyapoh Y, Ouermi D, Pignatelli S, et al. Antibiotic resistance in urinary tract bacteria in Ouagadougou. Pakistan Journal of Biological Sciences: PJBS. 2009;12(9):712–6.
Kaboré B, Ouédraogo GA, Cissé H, Ouédraogo HS, Sampo E, Zongo KJ, et al. (GTG) 5-PCR fingerprinting of multi-drug resistant Escherichia coli bacteria isolates from hospital in Ouagadougou, Burkina Faso. BMC microbiology. 2022;22(1):1–8.
Baizet C, Ouar-Epelboin S, Walter G, Mosnier E, Moreau B, Djossou F, et al. Decreased antibiotic susceptibility of Enterobacteriaceae causing community-acquired urinary tract infections in French Amazonia. Médecine et Maladies Infectieuses. 2019;49(1):63–8.
Sagna T, Somda W, Koné A. Antibiotic susceptibility of Escherichia coli and Klebsiella pneumoniae strains, urinary tract infections cases in Bobo-Dioulasso. Burkina Faso. 2019:172–8.
Eshetie S, Unakal C, Gelaw A, Ayelign B, Endris M, Moges F. Multidrug resistant and carbapenemase producing Enterobacteriaceae among patients with urinary tract infection at referral Hospital, Northwest Ethiopia. Antimicrobial resistance and infection control. 2015;4(1):1–8.
Khawcharoenporn T, Vasoo S, Singh K. Urinary tract infections due to multidrug-resistant Enterobacteriaceae: prevalence and risk factors in a Chicago Emergency Department. Emergency medicine international. 2013;2013.
Yadav KK, Adhikari N, Khadka R, Pant AD, Shah B. Multidrug resistant Enterobacteriaceae and extended spectrum β-lactamase producing Escherichia coli: a cross-sectional study in National Kidney Center, Nepal. Antimicrobial resistance and infection control. 2015;4:1–7.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Sciences de la Santé
This work is licensed under a Creative Commons Attribution 4.0 International License.
