The GC genotype of the MBL2 gene rs11003125 appears to be a protective factor in dengue infection in Burkina Faso

Authors

  • Lassina TRAORE
  • Mahamadi TIENDREBEOGO
  • Tegwindé Rébéca COMPAORE
  • Jean Claude Romaric Pingdwindé OUEDRAOGO
  • Mousso SAVADOGO
  • Teega-Wendé Clarisse OUEDRAOGO
  • Rogomenoma Alice OUEDRAOGO
  • Aristide Aziz Sidi TAPSOBA
  • Aminata Marie Simone Amsalet TRAORE
  • Wendyam Marie Christelle NADEMBEGA
  • Djénéba OUERMI
  • P Denise ILBOUDO
  • Florencia W. DJIGMA
  • Jacques SIMPORE

Keywords:

DENV,, rs11003125,, rs7096206,, MBL2 gene,, Burkina Faso.

Abstract

Introduction: Dengue fever is a viral infection transmitted to humans by the bite of infected Aedes mosquito. Genetic factors in the human host play a role in the onset and progression of the disease's severe forms. The present study aimed to investigate the susceptibility to dengue fever according to MBL2 gene GC genotype in Ouagadougou, Burkina Faso. Method: A transversal study was conducted from September 2022 to May 2023, involving 110 peoples. Human genomic DNA was extracted using the Favorgen kit and MBL2 gene polymorphisms genotypes were performed by real-time PCR using QuantStudio5. Results were analyzed using IBM SPSS Statistics 25 and Epi Info7 software.
Results: The participants had a mean age of 29.19 years with a range from 3 to 75 years. The population was predominantly female (60.91%). The combination of the two polymorphisms yielded 13.64% GC/CC and 0.91% GC/GG in the study population. The relationship was highly significant for both rs11003125 genotypes (GG and GC), with Chi-square values of 7.17 and 3.99, and p-values of 0.007 and 0.046, respectively. Conclusion: Our study has shown that the GC genotype of the MBL2 gene rs11003125 rs11003125 could be a protective factor in dengue infection in Burkina Faso

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Published

2024-10-19

How to Cite

TRAORE, L. ., TIENDREBEOGO, M. ., COMPAORE, T. R., OUEDRAOGO, J. C. R. P. ., SAVADOGO, M. ., OUEDRAOGO, T.-W. C. ., OUEDRAOGO, R. A. ., TAPSOBA, A. A. S. ., TRAORE, A. M. S. A. ., NADEMBEGA, W. M. C. ., OUERMI, D., ILBOUDO, P. D. ., DJIGMA, F. W. ., & SIMPORE, J. . (2024). The GC genotype of the MBL2 gene rs11003125 appears to be a protective factor in dengue infection in Burkina Faso. Sciences De La Santé, 47(1), 125–138. Retrieved from https://revuesciences-techniquesburkina.org/index.php/sciences_de_la_sante/article/view/1560

Issue

Vol. 47 No. 1 (2024): Janvier-juin

Section

Articles

License

Copyright (c) 2024 Sciences de la Santé

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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