High-risk HPV genotypes implicated in high-grade cervical intraepithelial neoplasia and invasive cervical cancer in Burkina Faso: systematic literature review

Abstract

Cervical cancer remains a public health problem. The objective of the study was to take stock of high-risk HPV genotypes involved in high-grade precancerous lesions and invasive cervical cancer in Burkina Faso. This was a systematic review of literature data available in April 2023 on HPVs involved in precancerous and cancerous lesions of the cervix in Burkina Faso, over a period of 07 years (January 1, 2015 to 31 December 2022). We used Google Scholar, PubMed and Google search engines according to PRISMA guidelines. The database search yielded 38 publications, distributed as follows: 19 articles on Google Scholar, 18 on PubMed and 01 on Google, of which 03 met our inclusion criteria. The average age of the patients was 45.96 ± 11.62 years with extremes of 21 and 84 years. Histologically, there were 53.94% infiltrating squamous cell carcinoma, 5.15% invasive adenocarcinoma, and 40.91% high-grade cervical intraepithelial neoplasia (CIN). Out of 330 samples, 69.23% were HPV positive. HPV 16, 18, 31, 33, 39, and 45 accounted for 6.96%, respectively; 23.38%; 9.95%; 17.91%; 8.47% and 6.96%. HPV 18, 33, 31 and 39 were the most common in high-grade CIN and invasive cervical cancer in Burkina Faso, accounting for 23.38%, 17.91%, 9.95% and 8.47% respectively.