Anticorps IgG et facteurs associés au paludisme clinique chez des enfants de moins de cinq ans vivant en zone endémique du paludisme au Burkina Faso

Authors

  • Oumarou OUEDRAOGO
  • Mariama Kaba CHERIF
  • Edith Christiane BOUGOUMA
  • Yéri Esther HIEN
  • Luisa NUNZIANGELI
  • Amidou DIARRA
  • Youssouf KABORE
  • Dinanibè KAMBIRE
  • Abdou Azaque ZOURE
  • Henri Gautier OUEDRAOGO
  • Alfred Béwendtaoré TIONO
  • Giampietro CORRADIN
  • Valentina MANGANO
  • David MODIANO
  • Yves TRAORE
  • Seni KOUANDA
  • Sodiomon Bienvenu SIRIMA
  • Roberta SPACCAPELO
  • Issa NEBIE

Keywords:

Antibodies, Clinical malaria, associated factors, Burkina Faso

Abstract

Introduction: malaria remains a major public health problem. Children under five years old are the main vulnerable group for this disease. A better knowledge of antimalarial immunity, of the factors associated with clinical malaria as well as their
consideration can contribute to adapting the management tools.
Methodology: clinical, socio-anthropological data and biological samples were collected during a cross-sectional survey. We used the protein microarray technique to measure the level of IgG antibodies to 36 Plasmodium falciparum antigens in
children under five years old belonging to three ethnic groups (Fulani, Mossi and Rimaibé) living in sympatry.
Results: there was no association between the variables age, sex, ethnicity, anemia, hemoglobin type, mosquito net use and clinical malaria. Children who had a higher level of antibodies directed against four antigens (MR214, MR231 MR232, MR233)
were free of clinical malaria.
Conclusion: the variables age, sex, anemia, type of hemoglobin did not influence the occurrence of clinical malaria in children. The presence of antibodies against (MR214, MR231 MR232, MR233) antigens could have contributed to their protection

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Published

2024-04-25

How to Cite

OUEDRAOGO, O. ., CHERIF, M. K. ., BOUGOUMA, E. C. ., HIEN, Y. E. ., NUNZIANGELI, L. ., DIARRA, A. ., KABORE, Y. ., KAMBIRE, D., ZOURE, A. A. ., OUEDRAOGO, H. G. ., TIONO, A. B. ., CORRADIN, G. ., MANGANO, V. ., MODIANO, D. ., TRAORE, Y. ., KOUANDA, S. ., SIRIMA, S. B. ., SPACCAPELO, R. ., & NEBIE, I. . (2024). Anticorps IgG et facteurs associés au paludisme clinique chez des enfants de moins de cinq ans vivant en zone endémique du paludisme au Burkina Faso. Sciences De La Santé, 45(1), 117–136. Retrieved from https://revuesciences-techniquesburkina.org/index.php/sciences_de_la_sante/article/view/1320

Issue

Vol. 45 No. 1 (2022): Janvier-Juin

Section

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