The GC genotype of the MBL2 gene rs11003125 appears to be a protective factor in dengue infection in Burkina Faso

Résumé

Introduction: Dengue fever is a viral infection transmitted to humans by the bite of infected Aedes mosquito. Genetic factors in the human host play a role in the onset and progression of the disease's severe forms. The present study aimed to investigate the susceptibility to dengue fever according to MBL2 gene GC genotype in Ouagadougou, Burkina Faso. Method: A transversal study was conducted from September 2022 to May 2023, involving 110 peoples. Human genomic DNA was extracted using the Favorgen kit and MBL2 gene polymorphisms genotypes were performed by real-time PCR using QuantStudio5. Results were analyzed using IBM SPSS Statistics 25 and Epi Info7 software.
Results: The participants had a mean age of 29.19 years with a range from 3 to 75 years. The population was predominantly female (60.91%). The combination of the two polymorphisms yielded 13.64% GC/CC and 0.91% GC/GG in the study population. The relationship was highly significant for both rs11003125 genotypes (GG and GC), with Chi-square values of 7.17 and 3.99, and p-values of 0.007 and 0.046, respectively. Conclusion: Our study has shown that the GC genotype of the MBL2 gene rs11003125 rs11003125 could be a protective factor in dengue infection in Burkina Faso